Search Results
- PKE-8BRCA-050 - 8-Br-cAMP
- cAMP analogue with an increased hydrolytical stability, activator of PKA, purity: > 98% (HPLC) ... More
- PKE-8CLCA-010 - 8-Cl-cAMP, sodium salt
- activates the holo enzyme complex of PKA with a high selectivity for type I, purity: > 99% (HPLC) ... More
- SY-A674563 - Akt1, CDK, PKA inhibitor A-674563
- A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. ... More
- PKI-BIMIX-005 - Bisindolylmaleimide IX
- Bisindolylmaleimide IX (Ro 31-8220) is a selective and ATP-competitive PKC inhibitor with an IC50 of 10 nM, whereas the IC50 for the inhibition of PKA is 900 nM. The IC50 values for the inhibition of the group A PKCs range from 5-27 nM and that for P ... More
- PKE-DBCA-050 - DB-cAMP, sodium salt
- membrane-permeable derivative of cAMP which activates the holo enzyme complex of PKA, purity: > 96% (HPLC) ... More
- PKI-ELGCA-100 - Ellagic acid
- Ellagic acid, a phenolic compound, inhibits the activity of CK2, CK1, PKA, PKC, FGR, LYN , SYK and GSK3, purity: > 97% (HPLC) ... More
- PKI-H007-005 - H-7
- H-7 is an inhibitor of PKC, PKA and PKG and also inhibits MLCK, purity: > 97% (HPLC) ... More
- PKI-H007-025 - H-7
- H-7 is an inhibitor of protein kinase C (PKC), cAMP- and cGMP-dependent protein kinase (PKA and PKG) and also inhibits myosin light chain kinase (MLCK). It induces apoptotic DNA fragmentation and cell death and inhibits telomerase activity in treated ... More
- PKI-H007-010 - H-7
- H-7 is an inhibitor of protein kinase C (PKC), cAMP- and cGMP-dependent protein kinase (PKA and PKG) and also inhibits myosin light chain kinase (MLCK). It induces apoptotic DNA fragmentation and cell death and inhibits telomerase activity in treated ... More
- PKI-H008-005 - H-8
- inhibitor of PKG and PKA and also inhibits MLCK, purity: > 98% (HPLC) ... More
- PKI-H008-025 - H-8
- Potent inhibitor of cGMP-dependent protein kinase (PKG, IC50 ~500nM) and cAMP-dependent protein kinase (PKA, IC50 ~1200nM). Also inhibits myosin light chain kinase (MLCK). ... More
- PKI-H008-010 - H-8
- Potent inhibitor of cGMP-dependent protein kinase (PKG, IC50 ~500nM) and cAMP-dependent protein kinase (PKA, IC50 ~1200nM). Also inhibits myosin light chain kinase (MLCK). ... More
- PKI-H089-005 - H-89
- H-89 is a cell permeable potent and selective inhibitor of PKA, PKG and PKC�, purity: > 98% (HPLC) ... More
- PKI-H089-025 - H-89
- Cell permeable potent and selective inhibitor of cAMP-dependent protein kinase (PKA, IC50 ~50 nM), cGMP-dependent protein kinase (PKG) and protein kinase C� (PKC�). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibite ... More
- PKI-H089-010 - H-89
- Cell permeable potent and selective inhibitor of cAMP-dependent protein kinase (PKA, IC50 ~50 nM), cGMP-dependent protein kinase (PKG) and protein kinase C� (PKC�). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibite ... More
- PKI-HA100-005 - HA-100
- inhibitor of MLCK, PKA and PKC, purity: > 97% (HPLC) ... More
- PKI-HA100-010 - HA-100
- Inhibitor of myosin light chain kinase (MLCK), cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). ... More
- PKI-HA100-025 - HA-100
- Inhibitor of myosin light chain kinase (MLCK), cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). ... More
- PKI-HA1004-010 - HA-1004
- Inhibitor of cAMP- and cGMP-dependent kinases (PKA/PKG, IC50 ~1-2uM). Also inhibits CaMKII, PKC and MLCK at higher concentrations. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmon ... More
- PKI-HA1004-025 - HA-1004
- Inhibitor of cAMP- and cGMP-dependent kinases (PKA/PKG, IC50 ~1-2uM). Also inhibits CaMKII, PKC and MLCK at higher concentrations. Intracellular Ca2+ antagonist with no effect on cardiac function. Causes selective pulmonary vasodilation during pulmon ... More
- PKI-HA1077-005 - HA-1077, fasudil
- inhibitor of ROCKII, Rho kinase, PRK2 and MSK1, also inhibits PKA, PKG, S6K1 and MAPKAP-K1b, MLCK and CaMKII, purity: > 98% (HPLC) ... More
- PKI-HA1077-025 - HA-1077, fasudil
- Inhibitor of ROCKII, Rho kinase, PRK2 and MSK1, also inhibits PKA, PKG, S6K1 and MAPKAP-K1b, myosin light chain kinase (MLCK) and Ca2+/calmodulin dependent protein kinase II (CaMKII). Cell permeable Ca2+ antagonist with antivasospastic properties. ... More
- PKI-HA1077-010 - HA-1077, fasudil
- Inhibitor of ROCKII, Rho kinase, PRK2 and MSK1, also inhibits PKA, PKG, S6K1 and MAPKAP-K1b, myosin light chain kinase (MLCK) and Ca2+/calmodulin dependent protein kinase II (CaMKII). Cell permeable Ca2+ antagonist with antivasospastic properties. ... More
- PKI-KT5720-100 - KT5720
- KT5720 is a potent, cell permeable, selective inhibitor of PKA, purity: > 99% (HPLC) ... More
- PKI-LAV-005 - Lavendustin A
- Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM). It inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 mM). ... More
- PK-MAPKAPK2-A010 - MAPKAPK2
- Human MAPKAPK2 (MAP kinase activated protein kinase 2), untagged, recombinant and active enzyme, activated, untagged, ecpressed in insect cells ... More
- PK-MAPKAPK3-A010 - MAPKAPK3
- Human MAPKAPK3 (MAP kinase activated protein kinase 3), untagged, recombinant and active enzyme, untagged, expressed in insect cells ... More
- PK-MPKPK5-A010 - MAPKAPK5
- human MAPKAPK5 (mitogen�activated protein kinase-activated protein kinase 5), recombinant and active enzyme ... More
- PKA-INVITRO-005 - PKA in vitro set
- Set contains the human PKA catalytic subunit alpha, the substrate Kemptide (labeled with Fluorescein) and specific PKA inhibitors (KT5720, H89, PKI) and can be used for in vitro enzymological studies. ... More
- K3027-1 - PKA Activity Assay Kit
- The B-Bridge cAMP-Dependant Protein Kinase A (PKA) Activity kit is designed to quantitatively measure PKA activity in Cell Lysate, Tissue Extracts and Buffer Samples and is species independent. The kit utilizes an immobilized PKA substrate bound to ... More
- PEP-HT31-001 - PKA anchoring inhibitor Ht31
- Ht31 peptide competes binding between PKA R-subunits and AKAPs, 23 aa (493-515) from thyroid protein Ht31, purity: > 90% (HPLC) ... More
- PEP-HT31-002 - PKA anchoring inhibitor Ht31
- This peptide is derived from amino acids 493-515 of the thyroid protein Ht31 and is predicted to form an amphipathic alpha helix. This helical region of the Ht31 protein binds to the dimerisation domain of type II regulatory subunits of the cAMP-depe ... More
- PEP-HT31-005 - PKA anchoring inhibitor Ht31
- This peptide is derived from amino acids 493-515 of the thyroid protein Ht31 and is predicted to form an amphipathic alpha helix. This helical region of the Ht31 protein binds to the dimerisation domain of type II regulatory subunits of the cAMP-depe ... More
- PEP-HT31P-002 - PKA anchoring inhibitor Ht31P (n.b.)
- 23 amino acid peptide derived from amino acids 493-515 of the thyroid protein Ht31. This negative control peptide contains two isoleucine to proline substitutions (I502P, I507P) which alters the helical structure of the peptide and abolishes binding ... More
- PEP-HT31P-005 - PKA anchoring inhibitor Ht31P (n.b.)
- 23 amino acid peptide derived from amino acids 493-515 of the thyroid protein Ht31. This negative control peptide contains two isoleucine to proline substitutions (I502P, I507P) which alters the helical structure of the peptide and abolishes binding ... More
- PEP-HT31P-001 - PKA anchoring inhibitor Ht31P (negative control)
- Ht31P negative control peptide does not compete binding between PKA R-subunits and AKAPs, (23 aa), purity: > 90% (HPLC) ... More
- PKA-COOK-096 - PKA kinase activity kit
- Spectrophotometric method for rapid and reliable quantification of PKA activity ... More
- PEP-PKA1-025 - PKA peptide substrate (Kemptide)
- PKA peptide substrate LRRASLG, purity: > 97% (HPLC) ... More
- PEP-FPKA1-010 - PKA peptide substrate (Kemptide) labeled with Fluorescein
- PKA peptide substrate, Fluorescein-Acp-LRRASLG, purity: > 98% (HPLC) ... More
- PKA-SIGNAL-005 - PKA signaling set
- Set contains modulators of PKA signaling pathway (Forskolin, 8-Br-cAMP, KT5720, H89, Rolipram). ... More
- PKA-PKI-100 - PKI, heat-stable protein kinase inhibitor of PKA
- PKI is a recombinant heat-stable protein kinase inhibitor PKI (full length, ... More
- PKA-PKI-500 - PKI, heat-stable protein kinase inhibitor of PKA (rabbit)
- The heatstable protein kinase inhibitor PKI is a key role player for the regulation of PKA activity and for localizing the catalytic subunit of PKAin the cell, also working as a nuclear scavenger. This relatively small protein (77 amino acids) is ext ... More
- PKI-PS1145-005 - PS 1145
- PS 1145 is a specific IKK inhibitor (IC50 = 88 nM), displaying no inhibitory activity against a panel of other tested (in vitro) kinases (PKA, PKC, CK2, MEK1, p38, Lck, Jnk, ERK2, EGFR, IC50 > 100 �M). Treatment of multiple myeloma cells with PS 114 ... More
- SY-H1152P - Rho Kinase Inhibitor
- A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kin ... More
- PKI-RTLN-025 - Rottlerin
- Rottlerin, also known as mallotoxin, was reported initially as a specific inhibitor of PKC delta with a 5- to 10-fold higher potency for PKC delta versus PKC alphaor PKC beta and a 13- to 33-fold higher potency than PKC epsilon. It also inhibits Ca2+ ... More
- PKI-STSP-002 - Staurosporine
- The cell permeable staurosporine, isolated from Streptomyces staurosporeus, is one of the most potent and widely used inhibitors of protein kinases initially proposed to inhibit protein kinase C (IC50 = 5 nM). Later it was shown that staurosporine ha ... More
- PKI-STSP-005 - Staurosporine
- The cell permeable staurosporine, isolated from Streptomyces staurosporeus, is one of the most potent and widely used inhibitors of protein kinases initially proposed to inhibit protein kinase C (IC50 = 5 nM). Later it was shown that staurosporine ha ... More
- PKI-Y27632-010 - Y-27632
- Y-27632 is a selective inhibitor of Rho-associated protein kinase p160ROCK with a Ki value of 140 nM. Ki values of PKC, cAMP-dependent protein kinase (PKA) and myosin light-chain kinase (MLCK) are 26, 25 �M and >250 �M, respectively. It also inhibits ... More
- PKE-CAMP-500 - cAMP, sodium salt
- activates the holo enzyme complex of cAMP dependent protein kinase PKA, purity: > 99% (HPLC) ... More
- PK-PKAR2BH025 - cAMP-dependent protein kinase regulatory subunit II beta (PKA, RII beta), human
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues. The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subuni ... More
- PK-PKAR2B025 - cAMP-dependent protein kinase regulatory subunit II beta (PKA, RII beta), rat
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues. The intracellular cAMP level regulates cellular responses by altering the interaction between the catatytic C and regulatory R subuni ... More
- PK-PKAHCA050 - cAMP-dependent protein kinase, catalytic subunit (PKA, Calpha) human
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart) regulating several cellular responses by altering the interaction between the catatytic C and reg ... More
- PK-PKA-CA050 - cAMP-dependent protein kinase, catalytic subunit (PKA, Calpha) mouse
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart) regulating several cellular responses by altering the interaction between the catatytic C and reg ... More
- PK-PKACR1A025 - cAMP-dependent protein kinase, holo enzyme complex, type I alpha (PKA C2RIA2)
- cAMP-dependent protein kinase, holo enzyme complex, type I alpha (PKA C2RIA2) ... More
- PK-PKACR2A025 - cAMP-dependent protein kinase, holo enzyme complex, type II alpha (PKA C2RIIA2)
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between th ... More
- PK-PKAR1A025 - cAMP-dependent protein kinase, regulatory subunit I alpha (PKA, RIalpha)
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between th ... More
- PK-PKAR2A025 - cAMP-dependent protein kinase, regulatory subunit II alpha (PKA, RII alpha)
- cAMP-dependent protein kinase (PKA) is an ubiquitous serine/theonine protein kinase present in a variety of tissues (e.g. brain, skeletal muscle, heart). The intracellular cAMP level regulates cellular responses by altering the interaction between th ... More