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C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa. It has long been recognised that CRP is closely related to immunology, inflammation and host defense and as a result it has been used as an inflammatory marker. However, the development of high-sensitivity CRP (hsCRP) ELISA kits has addressed its role in other clinical issues. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes.2-4 Normally circulating CRP is presenting only in trace amounts (<1 mg/ml)5,6 but can increase over 1,000-fold in an acute inflammatory state. Individuals with blood CRP levels <1 mg/ml, 1-3 mg/ml and >3 mg/ml are considered to have low, moderate and high risk, respectively, of CVD and myocardial infarction. Therefore, blood CRP determination has become a promising measure of CVD risk.