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A DNA sequence encoding the human Adiponectin protein sequence (containing the signal peptide sequence, and the mature Adiponectin sequence) was expressed in modified human 293 cells.

Adiponectin is a member of the ‘adipocytokines’ that are cytokines that are expressed from adipose tissues. Its general functions include regulation of energy homeostasis, hematopoiesis, inflammation and immunity. Adiponectin also plays an important role in fat metabolism, feeding behaviour, insulin sensitivity and is a negative regulator of hematopoiesis and immune responses. Adiponectin has been shown to suppress the expression of a number of membrane bound proteins involved in the infiltration of cells to sites of inflammation, including, vascular cell adhesion molecule 1 (VCAM-1), E-Selectin, and intercellular adhesion molecule-1 (ICAM-1). Furthermore adiponectin suppresses TNF induced adhesion of monocytes to endothelial cells through a mechanism involving the suppression of TNF-alpha induced I-kappa-B-alpha phosphorylation. Adiponectin also inhibits phagocytosis and bacterial lipopolysaccharide-induced production of TNF-alpha in mature macrophages. Conversely, TNF-alpha reduces the expression and secretion of adiponectin in differentiating primary human pre-adipocytes. For a recent review of adiponectin refer to Tilg H and Moschen AR (2006) Nat Rev Immunol. 6(10):772-783.