Go Back Activin RIA - Fc Chimera

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A DNA sequence encoding the signal peptide and extracellular domain of human Activin RIA (aa 1-123) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modified human 293 cells.

Activin RIA (also known as ACVR1 or ALK-2) is an activin type I receptor. The activin type I receptors transducer signals for a variety of members of the transforming growth factor (TGF) beta superfamily of ligands. This family of cytokine and hormones include activin, anti-m?llerian hormone (AMH), bone morphogenetic proteins (BMPs) and nodal. Despite the large amount of processes that these ligands regulate, they all operate through essentially the same pathway: A ligand binds to a type II receptor, which recruits and trans-phosphorylates a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) which it phosphorylates. The R-SMAD then translocates to the nucleus where it functions as a transcription factor. Activin RIA is expressed in normal parenchymal cells, endothelial cells, fibrobasts and tumor-derived epithelial cells. Defects in the receptor are a cause of fibrodysplasia ossificans progressive (FOP). For a recent review please see Chen et al. (2006) Exp Biol Med 231:534-544.