Go Back EGF R - Fc Chimera
Product Detail
| Cat # | 9021H |
| Size | 25 ug |
| Price |
$180.00 |
| Downloads | |
A DNA sequence encoding the signal peptide and extracellular domain of human EGF R (aa 1-525) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modified human 293 cells.
EGF R, also known as Epidermal growth factor receptor, is a member of the ErbB family receptors. EGF R is present in most, if not all, normal human epithelial cells. EGF R main function is as a receptor for EGF, but it also acts as a receptor for other members of the EGF family such as TGF-alpha, amphiregulin, and heparin-binding EGF-like growth factor. When EGF attaches to human EGF R it activates the enzyme tyrosine kinase, triggering reactions that cause the cells to grow and multiply. EGF R is a 479 amino acid glycoprotein that consists of an extracellular receptor domain, a transmembrane region, and an intracellular domain with tyrosine kinase function. For a recent review please see Herbst RS (2004) Int. J. Radiation Oncology Biol. Phys., 59(2): 21-26