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A DNA sequence encoding the signal peptide and extracellular domain of human TrkC (aa 1-428) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.

TrkC, also known as neurotrophic tyrosine kinase receptor type 3 (NTRK3), is a member of the tropomyosin-related kinase (trk or Trk) receptor family, consisting of TrkA, TrkB, and TrkC. Trk receptors bind neurotrophins, including neural growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophic factors 3 and 4/5 (NT-3, NT4/5). TrkC is located on the plasma membrane of neural cells such as the hippocampus, the cerebral cortex, and the granular cell layer of the cerebellum, and it specifically binds NT-3 as a ligand. TrkC is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain (ECD). TrkC has been implicated in the development of leukemias via gene fusion with the TEL gene and treatment with TrkC agonist antibodies delays disease progression of neuromuscular degeneration in susceptible mice. NT-3 has also been implicated in chronic pain and therefore, the sequestering of NT-3 by a soluble TrkC receptor could be used as a treatment against a number of pathological conditions involving chronic pain, including inflammatory, neuropathic, and cancer pain. For a recent review, please refer to Huang EJ, Reichardt LF (2003) Annu. Rev. Biochem. 72: 609-642.