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A DNA sequence encoding the signal peptide and extracellular domain of human TrkA (aa 1-405) was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modified human 293 cells.

The tropomyosin-related kinase (Trk) family consists of TrkA, TrkB and TrkC. These receptors each bind to and are activated by one or more of the neurotrophins, which include neural growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophic factors 3 and 4/5 (NT-3, NT-4/5). TrkA is the high-affinity receptor for NGF but also binds NT3 with lower affinity. TrkA is primarily expressed in neuronal cells, while an alternatively spliced isoform is expressed in non-neuronal cells. The TrkA receptor along with the p75 NTR and NGF regulate the growth, development, survival and repair of the vertebrate nervous system. Specifically, during development TrkA is involved in processes controlling axon and neurite growth, the regulation of dendrite architecture, patterning of neuronal innervation and modulation of proteins important for neuronal function such as neurotransmitters. In the adult nervous system TrkA is involved in regulating synaptic function and plasticity, neuron survival as well as mediating pain and inflammation. TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. For a review of the role of TrkA in neuronal signal transduction please refer to Huang EJ & Reichardt LF (2003) Annu Rev Biochem. 72: 609-42.