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A DNA sequence encoding the human IL-8 protein sequence (containing the signal peptide sequence, and the mature IL-8 sequence) was expressed in modified human 293 cells.

IL-8 is a member of the chemokine family. Chemokines are small secreted molecules containing 4 conserved cysteine residues and 2 disulfide linkages. IL-8 is a member of the CXC family of chemokines and is also known as CXCL8. IL-8 is predominantly produced by monocytes, T cells, NK cells and neutrophils and its expression is induced by IL-1 and TNF, as well as bacterial and viral products. IL-8 promotes the migration of leukocytes including neutrophils, monocytes, T and B-lymphocytes and basophils to the site of an infection to facilitate an immune response. Additionally, IL-8 promotes the adhesion and transmigration of neutrophils across the endothelium into tissues. IL-8 also exhibits chemotactic properties for non-leukocyte cell types such as keratinocytes, and smooth muscle cells as well as inducing the proliferation and chemotaxis of endothelial cells suggests it plays a role in angiogenesis. The role that IL-8 plays in the infiltration of neutrophils and angiogenesis suggests it may be involved in the pathogenesis of inflammatory diseases as well as tumor neovascularisation and progression. Several N-terminal processed forms of Il-8 are produced by proteolytic cleavage after secretion. In general, IL-8(1-77) is referred to as interleukin-8, with IL-8(6-77) being the most prominent form. For a recent review of the role of IL-8 in tumoral angiogenesis, please refer to Neuro-oncol. (2005): 7(2).