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A DNA sequence encoding the signal peptide and extracellular domain of human Cripto-1 (aa 1-169) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modified human 293 cells.

Cripto-1 (CR-1), also known as teratocarcinoma-derived growth factor-1 (TDGF-1), is a small glycoprotein that contains a single divergent EGF-like motif as well as a novel cysteine-rich domain termed the Cripto motif. It is the founding member of the EGF-CFC gene family, which is conserved among vertebrates, with homologs in chick, frogs, and zebrafish. Molecular genetic studies in fish and mice have revealed that EGF-CFC proteins play essential roles in early embryonic development in specification of the anterior-posterior and left-right body axes, as well as in formation of the primary germ layers during gastrulation. Cripto-1 is also an oncogenic growth factor involving tumorigenesis and cancer cell proliferation and survival. It is also believed that Cripto-1 may be involved in stem cell maintenance. For a recent review please see Strizzi et al. (2005) Oncogene 24:5731-5741