Go Back Flt-3 Ligand

Product Detail

A DNA sequence encoding the human Flt-3 Ligand protein sequence (containing the signal peptide sequence and the mature Flt-3 Ligand sequence) was expressed in modified human 293 cells.

Fms-like tyrosine kinase 3 (Flt-3) and its cognate ligand, Flt-3 ligand (Flt-3L), are essential growth factors involved in the survival and differentiation of hematopoietic progenitor and stem cells, specifically the development of NK cells, pre-B and pre-T cells, monocytes/macrophages and dendritic cells. Activation of Flt-3 promotes the survival and proliferation of early progenitor cells. Flt-3 receptor responses are cell type dependent and also influenced by other growth factors such as GM-CSF, G-CSF, IL-3 and EPO. Furthermore, Flt-3 is involved in lymphocyte development in conjunction with cytokines such as IL-3, IL-7 and IL-11. Expression of Flt-3 has been reported in peripheral blood mononuclear cells, thymus and non-immune somatic cells in the heart, lung, spleen, prostate, kidney, pancreas, skeletal muscle, intestine and liver. Both Flt-3 and Flt-3L play vital roles in the development of a number of human leukocyte malignancies including acute myelogenous leukemia (AML), acute promyelocytic leukemia (APL), B and T cell acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML) and myelodysplasia (MDS). Flt-3L also has a capacity to expand dendritic cells and may facilitate vaccine-induced immune responses against cancer and infectious pathogens. Additionally, due to its role in the development of NK cells, Flt-3L is also effective in promoting immunity against intracellular viral and non-viral pathogens. For a recent review, please refer to Drexler HG and Quentmeier H. (2004) Growth Factors. 22(2):71-3.