Go Back CRC-beta - Fc Chimera
Product Detail
| Cat # | 1103H |
| Size | 25 ug |
| Price |
$250.00 |
| Downloads | |
A DNA sequence encoding the signal peptide and extracellular domain of human CRC-? (aa 1-443) was fused to the Fc region of human IgG1 (aa 90-330). The chimeric protein was expressed in modified human 293 cells.
CRC-? (cytokine receptor common beta chain, CRC-beta, beta c) is the beta common receptor chain of GM-CSF receptor, IL-5 receptor and IL-3 receptor. For example, human GM-CSF receptor is composed of an alpha and a beta subunit. The beta subunit does not bind to GM-CSF by itself, however when assocated with the alpha subunit (GM-CSF R?) it forms a high affinity receptor. CRC-? has 3 potential N-glycosylation sites located in the extracellular domain. N-glycosylation of the beta subunit is essential for GM-CSF binding and signalling [Niu et al. (2000) Blood 95:3357-3362]. For a recent review please see Scott CL and Begley CG (1999) Int J Biochem Cell Biol 31:1011-1015.