Histamine H1 Receptor stable expressing U2OS Cell Line

Categories: Cells

Each vial of HiTSeeker HRH1 contains U2OS cells stably expressing Human Histamine H1 Receptor with no tag. We offer this cell line as a ?stable cell line? but we are now also offering vials of division-arrested cells (DA cells) in order to perform a small number of assays. Each vial of these DA cells contains 2.5 million cells, an enough number of cells to perform a complete experiment in a 96 well-plate or 384 well-plate. Innoprot HiTSeeker HRH1 Cell Line has been designed to assay compounds or analyze their capability to modulate Histamine H1 Receptor. When HRH1 binds to the Histamine a G protein is activated, which in turn, triggers a cellular response mediated by second messengers (Ca). This cell line has been validated measuring Calcium increase in the cytosol. The high reproducibility of this assay allows monitoring Histamine H1 Receptor activation process in High Throughput Screening.