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Product Detail
| Cat # | PPI-AS1949-010 |
| Size | 10 mg |
| Price |
$440.00 |
AS 1949490 is a potent and selective inhibitor of SHIP2. Inhibitory activity was tested using human and mouse SHIP2 resulting in IC50 values of 0.62 and 0.34 �M respectively. An approximately 30 fold higher IC50 was detected for structural related SHIP1 whereas no inhibition was found for other phosphatases (PTEN, synaptojanin and myotubularin, used concentration range: up to 50 �M AS 1949490). Inhibition of SHIP2 results in an increased phosphorylation of insulin signalling-related molecules, including Akt which in turn leads to activation of glucose metabolism and the reduction of gluconeogenesis. Chronic treatment of diabetic db/db mice with AS 1949490 considerably improved hyperglycaemia and glucose intolerance. Chemical name: 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2- carboxamide, Formula: C20H18ClNO2S Molecular Weight: 371.88 g/mol , Long Term Storage: 4 �C, Purity: ? 99 %, Solubility: Soluble to 100 mM in DMSO / ethanol