Go Back Rapamycin
Product Detail
| Cat # | PKI-RAPA-050 |
| Size | 50 mg |
| Price |
$1,592.00 |
Rapamycin potently inhibits downstream signaling from the mammalian target of rapamycin (mTOR) proteins which functions in a signaling pathway to promote tumor growth. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient quality and quantity. Rapamycin binds to the FK-506 binding protein (FKBP12, Kd = 0.2 nM) and the rapamycin/FKBP12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin selectively inhibits the phosphorylation and activation of p70 S6 kinase (p70S6K, IC50 = 50 pM). It prevents the translational activation of IGF-II and inhibits later signaling events such as p110Rb phosphorylation, p34cdk1 kinase activation, and cyclin A synthesis.