Go Back PD 325901
Product Detail
| Cat # | PKI-PD325-005 |
| Size | 5 mg |
| Price |
$152.00 |
PD0325901 is a highly potent and specific non-ATP competitive inhibitor of MEK1 /MEK2 (Ki of 1 nM). Compared to other known MEK inhibitors (such as its parent compound CI-1040/PD184352) PD0325901 has improved pharmacologic and pharmaceutical properties, higher bioavailability, increased metabolic stability and is currently in phase 1/2 clinical development. Upon treatment of human melanoma cell lines with PD0135902 suppressed ERK phosphorylation, growth inhibition as well as a proapoptotic, and antiangiogenic activity was determined. An oral administration of PD0325901 in mice inoculated with papillary thyroid carcinoma cells results in a significantly reduced tumor growth.