Go Back PD 169316
Product Detail
| Cat # | PKI-PD169-005 |
| Size | 5 mg |
| Price |
$480.00 |
PD 169316 is a potent and cell-permeable p38 MAP kinaseinhibitor (IC50 = 89 nM). It abrogates signaling initiated by both TGFbeta and Activin A, but not bone morphogenetic protein (BMP) 4. Inhibition of TGFbeta signaling is dose dependent and results in reduced Smad2 and Smad3 phosphorylation, nuclear translocation, and up-regulation of the TGFbeta target gene Smad7. Appearance: light orange solid, Purity: > 98%, Solubility: DMSO, Molecular Weight: 360.3 g/mol,Formula: C20H13FN4O2, CAS number: 152121-53-4,