Go Back Aloisine A
Product Detail
| Cat # | PKI-R107-010 |
| Size | 10 mg |
| Price |
$424.00 |
Aloisine A (RP107) is a cell-permeable compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25 with IC50 values of 150nM, 120 nM, 400 nM and 200 nM, respectively. Also inhibits activity of glycogen synthase kinase-3 (GSK-3) with IC50 values of 500 nM and 1.5 uM for the GSK-3 alpha and the GSK-3 beta isoforms, and c-Jun N-terminal kinase (JNK) with an IC50 of approximately 3-10uM. It inhibits cell proliferation by arresting cells in G1 and G2 phase.