Go Back Acadesine (AICAr)
Product Detail
| Cat # | PKE-AICAR-500 |
| Size | 500 mg |
| Price |
$560.00 |
AICAr is a cell-permeable compound whose phosphorylated metabolite activates AMP-activated protein kinase (AMPK). Incubation of rat hepatocytes with the non-phosphorylated AICAR results in accumulation of the monophosphorylated derivative within the cell. ZMP mimics both activating effects of AMP on AMPK, i.e. direct allosteric activation of phospho-transferase activity of AMPK. Unlike other methods for activating AMPK in intact cells AICAR does not perturb the cellular concentrations of ATP, ADP or AMP. Incubation of hepatocytes with AICAR activates AMPK due to increased phosphorylation, causes phosphorylation and inactivation of a known target for AMPK (3-hydroxy-3-methylglutaryl-CoA reductase), and causes almost total cessation of two of the known target pathways, i.e. fatty acid and sterol synthesis. Incubation of isolated adipocytes with AICAR antagonizes isoprenaline-induced lipolysis.