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Product Detail
| Cat # | PP-SHP1-040 |
| Size | 40 ug |
| Price |
$528.00 |
SHP-1 consists of two SH2 (Src homology 2) domains at the N terminus, followed by a catalytic domain (PTP domain) and a short C-terminal tail. The SH2 domains of SHP-1 play an important role in the regulation of enzyme activity. In the absence of stimulus, SHP-1 is inactive through allosteric inhibition by its N-terminal SH2 (N-SH2) domain. The binding of a phosphotyrosine (pY)-containing ligand leads to a conformational shift within the N-SH2 domain, upon which the PTP domain is released and accessible for substrate molecules. SHP-1 is predominantly expressed in hematopoietic cells and at a lower level in epithelial cells. It has been recognized as a negative regulator of various immune cell functions including antigen stimulation of B- and T-cells as well as neutrophil activity. Abberant SHP1 expression is associated with various diseases including acute myeloid leukemia, lymphomas, and multiple myelomas.