Go Back PPM1A, PP2Ca
Product Detail
| Cat # | PP-PP2CA-100 |
| Size | 100 ug |
| Price |
$528.00 |
The Ser/Thr-specific phosphatases can be divided into two major families: the PPP family, which includes PP1, PP2A, PP2B/calcineurin and the PPM family composed of PP2C. The PPM group has a strict requirement for divalent metal ions (Mg2+, Mn2+) and is insensitive to known PPP inhibitors. Mammalian PP2C was initially found to exist as two highly conserved isoforms which show approximately 70% sequence homology. By unsaturated fatty acids from lipoproteins activated PP2C alpha is involved in triggering apoptosis by dephosphorylation of the pro-apoptotic protein BAD. PP2C alpha also upregulates the expression and the activity of p53 and reduces the activities of CDK2 and CDK6 as well as MAPK.Protein Informations: PPM1A/PP2C alpha recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing (382 amino acids) and having a molecular mass of 46.6 kDa.Protein concentration: 1.0 mg/ml, Purity: > 95% by SDS PAGE, Specific activity: 8.000 U*/mg,