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Product Detail
| Cat # | PK-LYN-A010 |
| Size | 10 ug |
| Price |
$424.00 |
Lyn is a Src family kinase primary expressed in hematopoietic cells, predominantly in B cells. The modular structure is formed by a N-terminal tail, which is myristylated and palmitylated localizing Lyn to lipid rafts within the plasma membrane, a Src homology 3 (SH3) domain, a SH2 domain, the catalytic core and a C-terminal negative regulatory domain. Lyn is associated with the BCR in resting cells and serves upon antigen binding and BCR aggregation to phosphorylate tyrosine containing ITAM motifs on Ig-alpha/beta. The BCR signal is further amplified by phosphorylation of CD19 and Syk. On the other hand Lyn activation results in CD22 phosphorylation and the recruitment and activation of the tyrosine phosphatase SHP-1, which downmodulates BCR-mediated signaling.