Go Back anti-ATF6 a antibody, mouse monoclonal (37-1)
Product Detail
| Cat # | 73-505 |
| Size | 100 ug |
| Price |
$363.64 |
| Downloads | |
ATF6 (activating transcription factor 6) is an endoplasmic reticulum (ER) membrane-bound transcription factor activated in response to ER stress. When unfolded proteins accumulate in the ER, ATF6 is cleaved by regulated intramembrane proteolysis. The resulting amino-terminal fragment translocates to the nucleus and activates transcription by binding to ER stress-response elements present in the promoter regions of ER stress-inducible genes including those encoding ER chaperones and components of ER-associated degradation. ATF6 consists of two closely related factors, ATF6a and ATF6b, in mammals. ATF6a but not ATF6b plays a pivotal role in transcriptional control. The monoclonal antibody was characterized in the laboratory of Professor Kazutoshi Mori of Kyoto University. The antibody was produced from hybridoma cultured in serum-free medium and purified under mild conditions by propriety chromatography processes.