Go Back anti-c-Myc p-Ser62(human)antibody, monoclonal(33A12E10)
Product Detail
| Cat # | 71-161 |
| Size | 50 ug |
| Price |
$300.00 |
| Downloads | |
cMyc is a proto-oncogene, which is overexpressed in a wide range of human cancers. Myc gene encodes a transcription factor that regulates a great number of genes through binding on Enhancer Box sequences (E-boxes) and recruiting histone acetyltransferase. It can also act as a transcriptional repressor. It regulates cell growth, apoptosis, differentiation and stem cell self-renewal. Previous studies on the phosphorylation of c-Myc have suggested functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK), cell proliferation and cell cycle regulation. Phosphorylation at Ser62 is required for Ras-induced stabilization and is prerequisite for phosphorylation at Thr58 for its degradation.
Applications 1. Western blotting (~1ug/ml*, Fig.1) 2. ELISA Other applications have not been tested.