Rat Renal Mesangial Cells
Rat Renal Mesangial Cells (RRMC) provided from Innoprot are isolated from rat kidneys. Rat Mesangial Cells are cryopreserved immediately after purification and delivered frozen. RRMC are guaranteed to further expand for 10 population doublings in the condition provided by Innoprot. Renal mesangial cells (RMC) are perivascular pericytes located within the central portion of the glomerular tuft between capillary loops. Mesangial cells have a variety of functions including synthesis and assembly of the mesangial matrix, endocytosis and processing of plasma macromolecules, and control of glomerular hemodynamics via mesangial cell contraction or release of vasoactive hormones. As proliferation and matrix synthesis/degradation in vitro are regulated by cytokines and growth factors, cultured cells are an ideal tool for studying pathophysiological events such as mesangial expansion, scarring, and glomerulosclerosis.