Go Back MMP 17 (MT4-MMP) catalytic domain
Product Detail
| Cat # | 30100403 |
| Size | 200 ug / 1.0 ml |
| Price |
$6,656.00 |
Matrix metalloproteinases (MMPs) are Zn2+- and Ca2+-dependent endopeptidases which function in the turnover of extracellular matrix components [1]. Presently fifteen secreted MMPs and six membrane-types MMPs are known to be expressed in humans. The protein sequence of human MT4-MMP consists of 478 amino acid residues with a calculated Mr of 53 428 Da [2].
In analogy to other MT-MMPs the following domains and sequence regions are distinguished in active MT4-MMP: Catalytic domain, junction between catalytic domain and hemopexin domain, hemopexin-like domain and C-terminal sequence. MT4-MMP is anchored to cell surface membranes via glycosyl-phosphotidylinositol [3].
MT4-MMP transcripts are found mainly in brain, leukocytes, colon, ovary, and testis [2]. In addition, MT4-MMP mRNA is transcribed in invasive and noninvasive breast carcinoma cell lines [2, 4].